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Overview

The Cx43 membrane pore module produces a self-inserting that permits the passage of molecules < ~1000 kDa and has the ability to form gap junctions with neighboring cells.

Schematic

Depiction of connexin and its relationship to a connexon: (left) Connexins are tetra-membrane-spanning proteins whose N- and C-termini are located in the cytoplasm; (right) six connexins oligomerize to form a connexon. Figure by Totland et al. used under CC-BY-4.0 / cropped from original.

Depiction of connexin and its relationship to a connexon: (left)Connexins are tetra-membrane-spanning proteins whose N- and C-termini are located in the cytoplasm; (right) six connexins oligomerize to form a connexon. Figure by Totland et al. used under CC-BY-4.0 / cropped from original.

References
  1. Hsu, Y.-Y. (2025). Cx43 Cell: DNA Validation. 10.63765/xvxu3274